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Others, which were upregulated by TCPOBOP in sham, showed a trend towards upregulation in vehicle CLP but exhibited no further increase in response to TCPOBOP in CLP, except for Gdf15 (group 2)

doi: 10.1016/j.jcis.2018.12.036

Combination regimens that incorporate iron homeostasis modulation, anti-inflammatory effects, antioxidation, and tissue repair may better address OAs complicated and dynamic pathogenesis