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Ive spoken to one of the primary doctors/researchers involved with developing the original Botox pattern, technique, and dosing for chronic migraine and he agreed that technique and spreading the Botox around strategically and precisely will certainly lead to a better result as opposed to just quickly and less carefully throwing the injections in

42 The intended treatment plane is immediate subdermal to subcutaneous, with the treatment zone typically focused on the superior and lateral area of the buttocks

This is not a rare mutation, but rather a common variant that causes a change in how the gene functions