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The highest value of nitrification inhibitors should be realized in scenarios with a high risk of nitrate losses from leaching or denitrification, including the following conditions (Ruark, 2012): Tile-drained soils when leaching potential is high Wet or poorly drained soils Fields with nitrogen applied in the fall or spring prior to planting Urease Inhibitors Urease inhibitors are compounds that reduce volatilization losses of urea applied to the soil surface by slowing down urea hydrolysis

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