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Key points Parkinson disease (PD) is the fastest growing neurological disorder globally but, currently, no therapeutic intervention can modify disease progression and treatment is still based on levodopa (either alone or in combination with dopamine agonists or monoamine oxidase B or catechol- O -methyltransferase inhibitors) and device-aided therapies

The impact of oral CA administration on neuroinflammation in the 5xFAD mouse model, which exhibits accumulation of beta-amyloid, underscores the intricate relationship between oxidative stress, mitochondrial dysfunction, and neuroinflammation [81]

A protein-restricted diet may enhance the blood pressure-lowering and antiproteinuric effect of angiotensin-receptor blockers (ARBs), a standard therapy for hypertension and kidney diseases that cause proteinuria (Bellizzi 2013)

The above biological processes can cause iron overload in cells, which lays the foundation for the occurrence of ferroptosis