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The piriformis muscle and tendon travel over the top of the sciatic nerve as the nerve leaves the pelvis at the sciatic notch

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

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inflammatory bowel disease (IBD)