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It is morphologically characterized by mitochondrial wrinkling and a decrease in the number of mitochondrial cristae, an increase in membrane density and thickness, insignificant morphological changes in the nucleus (Stockwell et al., 2017)

For acute injuries, the traditional RICE protocol (rest, ice, compression, elevation) emphasizes immediate cold application during the first 48 hours when inflammatory processes are most active

J Cardiovasc Pharmacol 41:726733 Tricarico D, Barbieri M, Camerino DC (2000) Taurine blocks ATP-sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor

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