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The mechanisms through which progestins exert their therapeutic effects are the anti-estrogenic effects, anti-vasculogenic action, induction of apoptotic cascade in endometriotic cells, suppression of inflammatory pathways (as production of metalloproteinases), cell proliferation suppression, and also anti-neurogenic effects with inhibition of nerve growth within endometriotic lesions [59, 63, 64]

[DOI] [PubMed] [Google Scholar] Zhao J, Harada N, Kurihara H, Nakagata N, Okajima K

Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease

Moreover, the deficiency of the endothelial glucocorticoid receptor was found to regulate EndMT via the Wnt/-catenin pathway in DKD [38]