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This indicates that parameters used in some studies were suboptimal and compromised outcomes

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Meanwhile, as the preferred energy source for intestinal epithelial cells, butyrate can enhance the integrity of the intestinal physical barrier by increasing intracellular ATP levels, promoting the synthesis and assembly of tight junction proteins (181), inhibiting histone deacetylase, and upregulating the expression of anti-inflammatory genes (e.g., IL-10, TGF- ) in intestinal epithelial cellsreducing immune disorders caused by intestinal leakage