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Vanilla sweetens the tobacco without burying it, adds a creamy quality that softens the cured-leaf character, and provides the warmth that makes tobacco fragrances feel like a sweater in fragrance form

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The market's consolidation is evident, with a few key players holding a substantial share, highlighting their influence in shaping the competitive landscape

Interestingly, 2 of these studies were performed in patients who had been admitted for acute cardiovascular disease (myocardial ischaemia), and no short or long-term adverse cardiovascular effects appeared in the group of subjects that used bupropion, compared to the group that received standard care.18,19 These data were confirmed in a recent metaanalysis and in a new randomized, controlled clinical trial.20,21 A recent randomized, double-blind, controlled clinical trial examined the efficacy of a smoking treatment programme in a group of smokers who received intensive counselling for smoking cessation during admission, followed by continued counselling with automated interactive voice response telephone calls after discharge, as well as the treatment of their choice for a period of 3 months (NRT, bupropion or varenicline)