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Also known as Hypocretin-1 , Orexin-A plays a significant role in studies of orexin receptor activity, neuronal communication, and neurochemical signalling

The activation of VEGFR-1 leads to inflammation, while the activation of VEGFR-2 leads to angiogenesis (Farghaly et al., 2021)

In our study, we found that the increased A plaques firstly appeared in the cortex and hippocampus of earlier 8-week ethanol exposed APP/PS1 mice (in both 2BC and IP paradigms), and no A plaque was found even after 10 weeks ethanol exposure in WT mice, suggesting that chronic ethanol exposure did not directly result in A plaques but accelerate the A deposition

Ito T, Inden M, Ueda T, Asaka Y, Kurita H, Hozumi I (2020) The neuroprotective effects of activated 7 nicotinic acetylcholine receptor against mutant copperzinc superoxide dismutase 1-mediated toxicity