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[9] High-dose niacin (used to treat cholesterol) lacks human safety data in pregnancy and could theoretically affect the fetus (for example, by causing hypotension or altering lipid metabolism)

5 , eaav5490 (2019)

Furthermore, PTMs have been shown to modify the structures and functions of proteins and to be involved in important biological processes such as cell signaling and protein-protein interactions 89,90