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The cleavage of Corticosteroid-Binding Globulin (CBG) by neutrophil elastase is the molecular switch that releases free, biologically active cortisol precisely within the inflammatory micro-environment ( This may contribute to a state consistent with acquired local glucocorticoid resistance: the adrenal cortex may produce adequate cortisol (explaining normal serum levels), but the delivery mechanism is broken

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The size of these dense granules was larger (in the range of a few thousand angstroms) than previously reported for mitochondrial electron-dense clusters in mineralizing osteoid (ranging from 400 to 1000 angstroms) (Landis et al., 1977) The authors (Omelon et al., 2009) put together a hypothesis that apatite mineral dissolution in the osteoclast resorption zone increases the concentrations of free P i and Ca 2+

As an indirect antioxidant, SFN activates the Nrf2/Kelch-like ECH-associated protein 1 (Keap1)/Antioxidant response element (ARE) signaling pathway