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The strong interactions between METTYRTRP, observed through partial correlation networks at baseline confirms the connection between folate-mediated methionine formation, leading to methyl donation reactions that form the monoamine neurotransmitters serotonin, dopamine, and epinephrine 81,82

A dense plasma-lymphocytic infiltrate in the portal tracts with interface hepatitis is a hallmark of chronic AIH, observed in 8090% of cases in both adult and pediatric cohorts [4, 60,61,62,63]

Frequencies, Hazard-ratios (CI95%), Student's t-test or U-Mann-Whitney, and Kaplan-Meyer survival analysis (Log-Rank) were reported

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