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While in male rats in the VPA model, exogenous oxytocin was effective in treating core ASD symptoms due to deficits in the oxytocin pathway [31], in females in the same model (characterized by increased hippocampal and cortical levels of oxytocin and OXTR), the OXTR antagonist Atosiban demonstrated therapeutic efficacy [43]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Chen M., Yuan L., Chen B., Chang H., Luo J., Zhang H., Chen Z., Kong J., Yi Y., Bai M., et al