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In the developing world iodine deficiency is the major cause Very occasionally, the disease may be secondary to pituitary or hypothalamic disorders

Supplies dry and chapped skin with structural elements and helps to build up the lipid barrier of the horny layer of the epidermis

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Prospective randomized trials of lowering homocysteine levels with supplements of folic acid, vitamin B 12 , and vitamin B 6 against placebo over a 5-year period in patients with vascular disease or diabetes have not, however, shown a reduction of first event fatal or nonfatal myocardial infarction, nor have these supplements reduced the risk of recurrent cardiovascular disease after an acute myocardial infarct