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According to studies in animal models of glaucoma, the progressive RGCs death occurs mainly via apoptosis triggered by several interrelated mechanisms, including mechanical stress and impaired axonal transport of neurotrophic factors, glutamate excitotoxicity, as well as retinal ischemia and oxidative stress 8

In experimental and clinical studies, some drugs targeting metabolic pathways have demonstrated promising therapeutic effects, such as anti-inflammatory, anti-oxidative, and tissue repair promotion

This route provides consistent absorption and suits self-administration

Enfortumab vedotin plus pembrolizumab in previously untreated advanced urothelial cancer