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Preventing this decrease, with the administration of a SIRT-1 activator, reversed ROS bursts, increased downstream nuclear PGC-1a and Nrf2 expression, and attenuated increases in mitochondrial membrane potential and neuronal apoptosis induced by ischemia/reperfusion injury [78]

[88] [89] Additionally, carotenoids such as lutein and zeaxanthin found in the retina affect eye health from early development to aging, impacting conditions like ROP and AMD

found that Huangqi Baihe Granules could significantly enhance lung function, reduce lung wet/dry ratio, alleviate lung tissue injury, inhibit the formation of ROS and MDA, and increase SOD activity and GSH expression, and its mechanism of action may be to inhibit the activation of TLR4/NF-B p65/NLPR3 signaling pathway and reduce the release of downstream pro-inflammatory cytokines in lung tissue (Zeng et al., 2024)

Chemosphere 306, 135531