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In animal experiments, increases in VEGF were observed at both 2 h and 1 month following TBI, indicating impaired vascularity in both the short and long term (120, 121)

Auerbuch, V., Brockstedt, D

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The lactate accumulation from aerobic glycolysis acidifies the TME and promotes the M2 tumor-associated macrophage (TAM) polarization of these macrophages and microglial cells