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Examples Pioglitazone (Actos) Dosage Initial: 1530 mg once daily Maximum: 45 mg daily Rosiglitazone (Avandia) Dosage Initial: 4 mg daily as a single dose or in two divided doses Maximum: 8 mg daily as a single dose or in two divided doses Possible side effects include: Weight gain Fluid retention (edema), including macular edema Increased risk of heart failure (related to fluid retention) Osteoporosis and bone fracture Possible increased risk of bladder cancer with pioglitazone Alpha-glucosidase inhibitors Primary mechanism(s) of action Inhibition of intestinal -glucosidase and pancreatic -amylase, which reduces carbohydrate absorption

Most studies are small (n=3060), short-term (412 weeks), and the effects observed are modest and temporary melanin index returns toward baseline after supplementation stops

And so, you know, the people that know us know that my wife took the staff for I even had a chance to use it, and came back to me like a week later and said, What the hell is this

BMJ 344 , e3645 (2012)