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2 Methods 2.1 Study eligibility The systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist (Supplementary Table S1)

Seiwerth S, Brcic L, Vuletic LB, et al

Author contributions TX: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing original draft, Writing review & editing

More importantly, these identified specific OTU-metabolite associations show strong discrimination between healthy controls and CKD patients with ROC analyses