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Subjects were randomly assigned to receive cytisine (n = 1239) at a dose of 9 mg on day 0, gradually tapered to 1.5 mg on day 25, or placebo (n = 1233) for 25 days

10.1016/j.nantod.2020.100953 195 RuiS.SongL.LanJ.WangD.FengS.LuJ.et al (2023)

Practitioners are responsible for subject screening, dosing, informed consent and clinical record-keeping

Paracetamol, particularly in combination with weak opioids, is more likely than NSAIDs to cause rebound headache (medication overuse headache), although less of a risk than ergotamine or triptans used for migraines.[26] Paracetamol is contained in many preparations (both over-the-counter and prescription-only medications)