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Furthermore, recent CRISPRCas9 knockout screening led to the identification of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1), which is as an important contributor to the defense system against ferroptosis (Fig

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These findings suggest that AST protects dopaminergic neurons through suppression of ER stress and stabilization of the miR-7/SNCA regulatory loop, presenting a promising target for PD therapy ( In summary, AST demonstrates promising therapeutic potential in PD by targeting key pathological mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction

Sections were incubated with primary antibodies in PBS overnight at 4 C for immunohistochemistry