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Indeed, under hypoxic conditions, elephant seals upregulated expression of several genes along the GSH metabolic pathway, some of which also play a role in polyamine synthesis

It is also worth investigating whether the supplementation of with I 2 -Q 10 restores respiratory function in a CoQ-deficient cell culture model, as some CoQ derivatives suffer from a loss of function upon modification of the tail (e.g., Mito-Q)