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Description

Indeed, GSH is involved in protection against oxidative stress and the elimination of heavy metals and toxic endogenous metabolites, and it is also a source of cysteine

Consequently, there remains a critical need for a robust, label-free HILIC-MS/MS method capable of simultaneous and reliable quantification of a broad spectrum of sulfur-containing metabolites in complex biological matrices

doi: 10.1016/j.tcm.2016.03.001 342 ShaoXMLpez-ValdsHELiangJFeldmanJL

However, when present in normal concentrations, A does not induce oxidative stress, but when the amount of A increases significantly, as it does in AD, it evolves into a pro-oxidant that enhances oxidative stress, leading to disease progression (Rani et al., 2017)