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Goldenberg RM, Gilbert JD, Manjoo P, Pedersen SD, Woo VC, Lovshin JA

Neurobiology of addiction: a neurocircuitry analysis

Human evidence is extremely limited essentially one small Phase 1 safety trial and a tiny ~12-person knee study, with no long-term safety data

Research on intranasal peptide delivery indicates that molecules up to approximately 6000 Da can be absorbed, placing TB-500 within range but potentially at lower efficiency than smaller peptides like BPC-157