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The strength of evidence depends on the specific application you're considering

Riboflavin deficiency has been described predominantly in undernourished populations in low income countries, but accumulating evidence has shown that a suboptimal riboflavin status is more common than previously recognized among populations in developed countries

3.1.4 Roles of epigenetically mediated ferroptosis in I/R AKI Ubiquitination regulates signaling via mediating protein turnover, with deubiquitination reversing this process by detaching ubiquitin from substrates

If you want a practical breakdown, see Can I Take Glutathione and Vitamin C Together