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Aggravation of hyperthyroidism after heterologous prime-boost immunization with inactivated and adenovirus-vectored SARS-CoV-2 vaccine in a patient with Graves disease
In the last hundred years, scientists have understood this mechanism to include lipid peroxidation, hepatotoxicity, and liver damage through CYP2E1-mediated metabolism into toxic trichloromethyl and trichloromethyl peroxyl radicals
The Phase 3 SYNCHRONIZE trials use extended, flexible dose escalation, which is expected to substantially improve tolerability
