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Thus, epimutants exhibit variegation where the ratio of high ROS/insult-resistant to low ROS/insult-sensitive cells fluctuates in a cell population, and different states can be selected depending on the growth environment

7.1 Isolation techniques Isolation approaches differ in terms of their capacity to distinguish soluble elements from EXOs and the dimensions of the EXOs they can isolate (Le Gall et al., 2020)