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Thus, DNA methylation may act as a critical mediator, integrating environmental signals such as inflammation and oxidative stress, and ultimately influencing the gene expression pathways involved in AMD pathogenesis (Hunter et al., 2012)

While sugar-sweetened beverages and refined grains are low-quality carbohydrates that raise the risk of obesity, heart disease, and type 2 diabetes, complex and high-fiber carbohydrate foods, such as beans and lentils, vegetables and fruits, and whole grains, have been associated with weight loss and decreased risk of heart disease and type 2 diabetes

NAPQI will then bind to the cellular macromolecules, including proteins, lipids, and nucleic acids, resulting in centrilobular liver injury and hepatocyte death (McGill et al., 2012

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