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PMID: 40729432 Cancer Cell Int2022 Oct 7;22(1):304

Navigating redox imbalance: The role of oxidative stress in embryonic development and long-term health outcomes

Importantly, the circadian interplay between PER2 and p53 forms a regulatory feedback loop in which p53 suppresses PER2 expression, while PER2 stabilizes p53 by inhibiting MDM2-dependent ubiquitination, linking circadian rhythm to cellular stress responses and tumor suppression ( 4.1.13 morgue morgue is a unique ubiquitin pathway protein in Drosophila notable for its dual-domain structure containing an F-box and a non-catalytic E2-conjugase domain (Wing et al., 2002)