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Chronic infection and inflammation can deplete endogenous antioxidants such as glutathione, catalase, and vitamins C and E, resulting in amplification for the oxidative stress and cellular damage, and this may have negative effect by causing damage to the alveolar-capillary membrane which causes increased permeability, pulmonary edema, decreased gas exchange, and prolonged oxidative stress causing inflammation, fibrosis, and long-term lung damage

D.GambleM

There was this quiet moment right after I walked off stage, diploma in hand, when it all hit me

In the end, numerous clinical studies and controlled clinical trials on the assessment of the effectiveness of these novel topical formulations in melasma management are summarized