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Studies are not entirely consistent, but they mostly report an increase in Akkermansiaceae and Methanobacteriaceae, and a decrease in SCFA-producing Bacteroidetes and Clostridia clusters (Atarashi et al., 2011

2019 Feb;16(2):223-234

Unveiling clinical and genetic landscapes of MMA and CBS: insights from whole exome sequencing in a tertiary care setting

Active principles in herbs can disrupt bacterial cell walls and membranes, modify critical genetic components, induce mutations leading to cell damage, and ultimately cause bacterial cell death