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In vitro and in vivo analyses suggested that MEK inhibitor-induced PDAC heterogeneity facilitates the rapid proliferation of treatment-resistant cells ( CasRx can precisely and effectively silence the expression of mutant KRAS G12D in PDAC cells and, further, eliminate KRAS G12D -related downstream signaling, thereby, making PDAC cells sensitive to gemcitabine and inhibiting tumor growth ( TABLE 1 Therapies for PDAC directly focused on KRAS mutation or indirectly on related effector

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6 Glutathione: central player in redox regulation and cellular defense Glutathione (GSH) is a tripeptide made of -glutamate, cysteine, and glycine that acts as the main non-enzymatic redox buffer in cells and plays a pivotal role in maintaining redox equilibrium

Cipriani V, Lors-Motta L, He F, Fathalla D, Tilakaratna V, McHarg S, et al