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Weight gain leads to an increase of fat cell size (hypertrophy) as well as number (hyperplasia), which results in the decline of their functional capability and the increase in their secretion of free fatty acids (FFAs) and cytokines like TNF- and IL-6 that promote inflammation

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Novartis supported the expansion application with topline data from the Phase III NATALEE trial, in which treatment with Kisqali led to a significant improvement in disease-free survival versus standard adjuvant endocrine therapy alone, according to the company