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If youre an older adult, B12 absorption naturally decreases with age and supplementation is broadly recommended regardless of GLP-1 use

For non-diabetic users the question is whether both are needed: tirzepatide is far stronger for weight loss at 5 mg and above, while metformin is cheaper, oral, and more modest

The B12-induced increment in methylation levels of each of these DML negatively correlated with the CCL3 expression level assessed by RT-qPCR ( Figure 4 )