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Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes

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Plasma thiosulfate concentrations, sampled from the volunteers were 11.3 ( 1.1) mg/l (n = 26) and urine thiosulfate concentrations were 2.8 ( 0.2) mg/l (n = 24)