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Based on this, specific markers related to ROS-induced modifications can be defined and summarized in Figure 1

It is a frequent and life-threatening complication, particularly in Intensive Care Units (ICU), where it commonly arises in post-operative patients (24), hyperoxemia induced by mechanical ventilation or extracorporeal membrane oxygenation (25), systemic inflammation (26), and the metabolic effects of critical illness (27, 28), all of which may contribute to neuronal damage and cognitive dysfunction

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Gaussian 16 was used, employing the XQC convergence criteria, to calculate partial charges for the Cu ions and their surrounding histidine coordinating atoms at the B3LYP/6-31G* level 54