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In other words, the gastrointestinal side effects were milder and less frequent than what researchers typically see with GLP-1 and GIP agonists

Furthermore, KEGG pathway enrichment analysis demonstrated significant enrichment of purine metabolism, valine, leucine, and isoleucine biosynthesis, arginine biosynthesis, the pentose phosphate pathway (PPP), and histidine metabolism in LPS-induced pneumonia, while papain-induced pneumonia primarily enriched the one-carbon pool by folate, alanine aspartate, and glutamate metabolism, glycine, serine, and threonine metabolism, cysteine and methionine metabolism, and the PPP (Figures 2C, E)

To determine the point at which mitochondrial Fe-S protein function is compromised by cystine starvation, we assessed respiratory complex activity in cells subject to cystine deprivation for 096 h that were concomitantly treated with ferrostatin-1 to prevent the induction of ferroptosis

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