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Factors such as the insufficiency of activating enzymes like NAD-(P)H oxidoreductase, enhanced drug efflux, and DNA repair processes contribute to the development of resistance in cancerous cells treated with MTMs [71]

The Importance of Glutathione Maintaining optimal levels of glutathione is essential for several reasons: Detoxification : Glutathione helps neutralize toxins and heavy metals, facilitating their removal from the body