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Altered gut microbiome and intestinal pathology in Parkinsons disease

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These opposing effects likely reflect the temperature-dependent behaviour of lipid membranes: a low temperature reduces membrane fluidity and impairs several cellular processes, prompting adaptive changes such as increased incorporation of unsaturated fatty acids to restore membrane functionality 3

[ 3 ] Early experiments in animal models suggested that the administration of DSIP can increase slow-wave sleep in these models and potentially regulate sleep patterns