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Clin Pediatr (Phila) 2003

LPS stimulation in microglia increases nitric oxide (NO) and pro-inflammatory cytokines IL-6 and IL-1, whose levels correlate positively with AP-1 and NF-B expression

Collectively, these results demonstrate that deletion of Keap1 (and subsequent NRF2 hyperactivation) drives CD8 + T cells toward dysfunction, marked by reduced expansion, diminished effector function and acquisition of a T tex phenotype

A small, randomized, controlled, crossover trial involved 18 participants, average age 51 years, with obesity and prediabetes who underwent a 10-week intervention with cinnamon (4 grams per day) or placebo