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J Clin Diagn Res

Of note, the androgen modulation of AMP-activated protein kinase (AMPK) activity might also indirectly influence PI3K signaling, thus promoting glucose uptake, protein synthesis, and mitochondrial biogenesis in skeletal muscle [96, 97]

Increases energy and reduces fatigue

Therefore, in principle any changes are reversible, and indeed, histone acetylation levels can be decreased and increased, respectively, by inhibiting acetyltransferases (Baell et al, 2018