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Numerous studies reveal that Nrf2 benefits cell survival and proliferation in various ways, ranging from redox homeostasis and drug/xenobiotic metabolism to DNA repair (88)

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ER stress The ER is an essential component of endomembrane system of cells which provide a great many of functionality, such as regulating cellular calcium (Ca 2+ ) concentration, involved in lipid synthesis and transportation, and thus accelerating protein folding (Figure 2) [87]

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