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Exercise-induced upregulation of miR-126 promoted angiogenesis and protected the heart from myocardial I/R injury and myocardial infarction through targeting PI3KR2 and SPRED1

It downregulates pro-inflammatory cytokines calming chronic redness, post-treatment reactivity, and barrier-related irritation at the immune level

Thus, the serine residue at position 114 of NHR-49 and potentially others within the hinge-region of NHR-49 were detected across multiple experiments which used both ectopically overexpressed and endogenously tagged forms of NHR-49