glutathione s-transferase pi gstp gsh Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione transferases as mediators of

Ferroptosis in diabetes mellitus Ferroptosis in diabetes clinical studies Iron overload is correlated with increased diabetes risk by multi-level evidence DM is a chronic condition characterized by persistently high blood glucose levels beyond the normal range

Oligodendrocytes in the white matter of the spinal cord are rich in unsaturated fatty acids and are susceptible to damage caused by ferroptosis

Oxidative stress may actually promote the onset of eye diseases such as cataracts and AMD (Age-related Macular Degeneration) (14-15)

It modulates IL-1 and IL-18 release via inflammasome activation, linking lysosomal Ca 2+ ion fluxes to proinflammatory cytokine production ( 2+ ion channels are regulators of calcium signaling in macrophage-mediated immune functions