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Quantitative detection and metabolic profile analysis of metabolites of tricarboxylic acid cycle and amino acids in psoriasis serum before and after receiving monoclonal antibody treatment by one-pot GC-MS derivatization

While this putative kinetically stabilising site has been suggested for drug discovery 28,35 , our findings nonetheless suggest alternative frameworks in the context of filament formation (instead of the previously suggested tetrameric state) that should be considered for targeting the CBS regulatory domain (discussed below)

Of note, colchicine treatment did not alter body weight or LDL cholesterol levels in mice

USA 113 , E3451E3460 (2016)