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Evidence base: Tyrosinase inhibition multiple in vitro and clinical studies confirm glutathiones capacity to inhibit tyrosinase and shift melanogenesis toward lighter phaeomelanin production Published RCTs randomised controlled trials have documented measurable skin lightening outcomes with IV glutathione administration compared to placebo in Asian skin type populations, including Fitzpatrick IIIV the most prevalent skin types among Mumbai patients Hepatic and antioxidant support extensive published evidence from hepatology and immunology supports IV glutathiones systemic detoxification and antioxidant mechanisms Safety profile when administered in appropriate concentrations by qualified medical professionals, IV glutathione has a well-established safety record across international clinical practice At Brilliance Cosmocare, IV Glutathione therapy is administered strictly within evidence-supported concentration ranges by trained medical staff not administered in the unregulated, high-dose formats that carry documented safety concerns

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doi: 10.1016/j.redox.2018.101072 131 DingLZhangFBLiuHGaoXBiHCHuangLet al

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