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R J Maude reports support for the present manuscript from Wellcome Trust (grant 220211) as it provides core funding for Mahidol Oxford Tropical Medicine Research

With regard to Graves disease (GD) and the periocular process frequently associated with it, namely thyroid-associated ophthalmopathy (TAO), IGF-IR has been found overexpressed in orbital connective tissues, T and B cells in GD and TAO

They are involved in the regulation of immune checkpoint molecules such as PD - L1, thereby facilitating tumor cells ability to evade the immune system