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In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion

While some people report subtle changes in energy or mental clarity within the first week, most clinical studies and anecdotal feedback suggest that it takes 4 to 8 weeks of consistent use to see significant results

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Samples were heated at 95 C for 10 min then cooled off at room temperature