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Since ancient times, pineapple as the main source of bromelain has been widely applied against inflammation disorders ( More recently, the inflamed colon tissue was used as a model to evaluate the bromelain anti-inflammatory role

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Ebselen belongs to the NIH Clinical Collection compound library, that gathers substances that are not currently clinically used, but with history of usage in clinical trials in humans

Acknowledgments The authors would like to acknowledge the following individuals at Jilin University: Chunhui Wei for their technical support